Marinate chicken in buttermilk for at least 20 minutes.
Mix flour with garlic powder, smoked paprika, pepper, and salt in one dish; place panko in another.
Dredge chicken in seasoned flour, dip back in buttermilk, then coat with panko.
Pan-fry in oil over medium heat, 5-6 minutes per side, until golden and internal temperature reaches 165°F.
Simmer honey, hot sauce, butter, red pepper flakes, cayenne, vinegar, and salt over low heat until smooth.
Drizzle warm glaze over crispy chicken and serve immediately.